Thymosin Alpha 1: Structure and Testing

Thymosin alpha 1 is a 28-residue peptide that PubChem lists as C129H215N33O55, with a molecular weight of 3108.3 g/mol. An NMR study in a trifluoroethanol and water mixture reported a helix across residues 14 to 26, and testing confirms identity by mass spectrometry and purity by HPLC.

What does thymosin alpha 1 look like structurally?

The NMR model showed two stable regions: a helix and a distorted helical N-terminus built from double beta-turns. Trifluoroethanol promotes helix formation. The result describes those solvent conditions only.

How is thymosin alpha 1 tested before research use?

Labs test it mainly by HPLC and mass spectrometry. The peptide COA guide explains how to read each result.

HPLC purity reports peptide-related impurities by UV absorbance. Net peptide content is a separate measurement that accounts for water and counter-ions. Current certificates are on the COA page.

How is the lyophilised powder stored?

Sealed, cold, dry and dark. The peptide storage guide covers stability in more detail.

Thymosin alpha 1 is supplied for in-vitro work as Thymosin Alpha-1 5mg. It is a different peptide from thymosin beta-4, which has its own sequence.

Research use only

This material is supplied for in-vitro laboratory research only. It is not for human or animal use, and nothing here is dosing or usage guidance.

Sources

• •Thymosin Alpha-1 compound record. PubChem, US National Library of Medicine.
• •NMR structure of human thymosin alpha-1. Biochemical and biophysical research communications, 2011.