Store lyophilised peptides at −20°C, dry and away from light, and let the vial reach room temperature before opening. Reconstituted material is far less stable than powder, so it is held for much shorter periods. Four degradation routes drive this: hydrolysis, deamidation, oxidation and aggregation.

How long do peptides last in storage?

Lyophilised powder lasts longest, because freeze-drying removes the water that hydrolysis needs.

Form	−20°C	2–8°C	Room temperature
Lyophilised	12–24 months	3–6 months	Weeks to months (avoid if possible)
Reconstituted	Up to 3 months	Up to 4 weeks	Hours to days only

Opening a cold vial lets condensation reintroduce moisture. Repeated freeze-thaw cycles drive aggregation and speed hydrolysis, so single-use aliquots suit material accessed often.

What degrades a stored peptide?

•Hydrolysis: moisture cleaves the amide bonds of the peptide backbone.
•Deamidation: asparagine and glutamine lose their amide group, faster at higher pH and temperature.
•Oxidation: methionine, cysteine, tryptophan and histidine are prone, and light and oxygen speed it up.
•Aggregation: larger or more hydrophobic peptides self-associate under thermal or mechanical stress, and cooling does not reverse it.

Reconstitution & storage log

One row per vial, from the day it is reconstituted to the day it is discarded. The columns are the ones that make a result traceable back to a specific batch.

Date reconstitutedStarts the clock on the reconstituted shelf life.
CompoundAs printed on the vial, not an abbreviation.
Batch / lot numberThe only field that ties the vial to a COA.
Vial contents (mg)Label strength, before dilution.
Diluent usedBacteriostatic or sterile water — they behave differently.
Diluent volume (mL)With the mg above, this fixes the concentration.
Concentration (mg/mL)Derived, but worth writing down so it is not recomputed each time.
Storage temperatureWhere it actually sat, not where it was meant to.
Freeze-thaw cyclesThe variable most often blamed and least often recorded.
Date opened / first drawSeparates 'reconstituted' from 'in use'.
Date discardedCloses the record.
NotesCloudiness, colour change, anything anomalous.

Download as CSV12 columns · opens in Excel or Sheets

Keep vials dry with desiccant and shield them from light in amber glass or foil. Label compound, batch number, concentration and date. Glass also limits adsorption of small hydrophobic sequences onto plastic. NAD+ is especially sensitive to moisture and light, so store it desiccated at −20°C.

Cloudiness or visible particulate can suggest aggregation, but only HPLC re-testing confirms purity has held.

Related reading: How research peptides are made explains why lyophilised powder is the standard storage form.

Research use only

These peptides are supplied strictly for in-vitro laboratory research. This article is educational and is not medical advice.

Peptide Storage Guide: How to Maximise Stability

How long do peptides last in storage?

What degrades a stored peptide?

Reconstitution & storage log

Research use only

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