Kisspeptin-10: Structure and Mechanism

Kisspeptin-10 is a decapeptide amide, the C-terminal fragment of the kisspeptins encoded by the KISS1 gene. PubChem lists it as C63H83N17O14, molecular weight 1302.4 g/mol. In the laboratory it serves as a defined ligand for KISS1R, a G protein-coupled receptor, in cell-based work.

What does kisspeptin-10 bind to?

It binds KISS1R, also called GPR54, a G protein-coupled receptor. A cell-culture study in bovine granulosa cells examined microRNA-1246 as an intermediate in the signalling downstream of the peptide. It is cell-culture mechanism work only.

What are its specifications?

How is kisspeptin-10 material tested?

Identity and purity are checked separately. Mass spectrometry confirms the molecular identity, and HPLC reports purity as the main peak's share of total peak area. Read each certificate against both, using the guide to how to read a peptide COA and the explainer on HPLC purity. Certificates are listed on the COA page.

Material sold as kisspeptin-10 for research should match the amidated structure above, because the free-acid form is a different molecule with a different mass.

Research use only

Sold strictly for in-vitro laboratory and research use only. Not for human or animal use, and no therapeutic claim is made.

Sources

• •Kisspeptin-10 compound record. PubChem, US National Library of Medicine.
• •Kisspeptin-10 Promotes Progesterone Synthesis in Bovine Ovarian Granulosa Cells via Downregulation of microRNA-1246. Genes, 2022.